Ge 4:25 And Adam knew his wife again, and she bore a son and named him Seth, "For God has appointed another seed for me instead of Abel, whom Cain killed."
26 And as for Seth, to him also a son was born; and he named him Enosh. Then men began to call on the name of the LORD.
In contrast to Cain's descendants, we now have here presented before us the godly line of Seth.
Seth is a type or picture of the Lord Jesus Christ resurrected. In Abel, we have Him murdered. In Seth, we have Him resurrected so to speak.
Seth's line was characterized by godliness. They were God-centered people. There were, no doubt, advances in industry, civilization and technology like that of the line of Cain's, but their primary and main pursuit is God.
The word "call" can also mean proclaim. It was during this time that a revival of sorts took place. Men began to call on the Lord and proclaim Him.
Moses is teaching his Israelite readers that they should trace their line in Seth and follow his and his descendants example. They are to separate from the pagan nations and live God-centered lives.